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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RAF1 All Species: 26.06
Human Site: S222 Identified Species: 52.12
UniProt: P04049 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04049 NP_002871.1 648 73052 S222 R R M R E S V S R M P V S S Q
Chimpanzee Pan troglodytes XP_001155232 648 73032 S222 R R M R E S V S R M P V S S Q
Rhesus Macaque Macaca mulatta XP_001086034 615 69495 N189 T M C V D W S N I R Q L F S Q
Dog Lupus familis XP_859234 648 72974 S222 R R M R E S V S R M P V S S Q
Cat Felis silvestris
Mouse Mus musculus Q99N57 648 72899 S222 R R M R E S V S R M P A S S Q
Rat Rattus norvegicus P11345 648 72910 S222 R R M R E S V S R M P A S S Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P05625 647 73106 S222 R R M R E S V S R I P V S S Q
Frog Xenopus laevis P09560 638 71941 M213 H T L P S L T M R R I G E S V
Zebra Danio Brachydanio rerio NP_571514 643 72503 T213 R R M R E S L T R I P S S S V
Tiger Blowfish Takifugu rubipres NP_001033078 663 74935 R238 L P P L T S R R M R E S L T R
Fruit Fly Dros. melanogaster P11346 782 88616 M345 G T A V R F N M S S R S R S R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q07292 813 90389 L252 R S V A E I V L A N L A P T S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 94.9 98.7 N.A. 97.6 98.3 N.A. N.A. 94.5 85.3 75.1 80.5 37.4 N.A. 36 N.A.
Protein Similarity: 100 100 94.9 99.2 N.A. 98.3 98.4 N.A. N.A. 97.6 90.7 83.9 87 52.9 N.A. 51 N.A.
P-Site Identity: 100 100 13.3 100 N.A. 93.3 93.3 N.A. N.A. 93.3 13.3 66.6 6.6 6.6 N.A. 20 N.A.
P-Site Similarity: 100 100 33.3 100 N.A. 93.3 93.3 N.A. N.A. 100 20 86.6 20 13.3 N.A. 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 9 9 0 0 0 0 9 0 0 25 0 0 0 % A
% Cys: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 67 0 0 0 0 0 9 0 9 0 0 % E
% Phe: 0 0 0 0 0 9 0 0 0 0 0 0 9 0 0 % F
% Gly: 9 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % G
% His: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 9 0 0 9 17 9 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 9 0 9 9 0 9 9 9 0 0 9 9 9 0 0 % L
% Met: 0 9 59 0 0 0 0 17 9 42 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 9 9 0 9 0 0 0 0 0 % N
% Pro: 0 9 9 9 0 0 0 0 0 0 59 0 9 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 59 % Q
% Arg: 67 59 0 59 9 0 9 9 67 25 9 0 9 0 17 % R
% Ser: 0 9 0 0 9 67 9 50 9 9 0 25 59 84 9 % S
% Thr: 9 17 0 0 9 0 9 9 0 0 0 0 0 17 0 % T
% Val: 0 0 9 17 0 0 59 0 0 0 0 34 0 0 17 % V
% Trp: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _